Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax

被引：62

作者：

Cencetti, C. ^{[1
]}

Bellini, D. ^{[1
]}

Pavesio, A. ^{[2
]}

Senigaglia, D. ^{[2
]}

Passariello, C. ^{[3
]}

Virga, A. ^{[3
]}

Matricardi, P. ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy

[2] Anika Therapeut Inc, Bedford, MA 01730 USA

[3] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 03期

关键词：

Nonwoven; Wound healing; Silver; Gellan; Hyaff (R); ANTIBACTERIAL; HYALURONAN;

D O I：

10.1016/j.carbpol.2012.07.005

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff (R) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1362 / 1370

页数：9

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