Asymmetric synthesis .39. Synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams.

被引:16
作者
Micouin, L
Bonin, M
Cherrier, MP
Mazurier, A
Tomas, A
Quirion, JC
Husson, HP
机构
[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE
[2] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,PHYS LAB,F-75270 PARIS 06,FRANCE
关键词
D O I
10.1016/S0040-4020(96)00339-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of 3-substituted piperidines in enantiomerically pure form has been synthesized from lactam 1 via the bromo derivative 2i. t-Butyl acetate and 5-methylpyridine derivatives 2g and 2h were obtained optically pure by direct alkylation of 1 with corresponding halides. Azido, amino or benzyloxy products were obtained by diastereoselective substitution of 2i. Copyright (C) 1996 Elsevier Science Ltd
引用
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页码:7719 / 7726
页数:8
相关论文
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