New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes

被引：50

作者：

Peyrefitte, S

Kahn, D

Haenlin, M

机构：

[1] Ctr Dev Biol, CNRS, UMR 5547, F-31062 Toulouse, France

[2] INRA, CNRS, Lab Biol Mol Relat Plantes Microorganismes, F-31326 Castanet Tolosan, France

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 104卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

Drosophila; basic helix-loop-helix; genome;

D O I：

10.1016/S0925-4773(01)00360-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basic helix-loop-helix (bHLH) proteins represent an evolutionary conserved class of transcription factors that are known to play important roles in cell determination and differentiation during animal embryonic development. Following an exhaustive search of the complete Drosophila genome sequence using a PSI-BLAST strategy, we identified 19 new genes, bringing the total number of bHLH-encoding genes in the Drosophila genome to 56. These new genes belong to various subfamilies of bHLH transcription factors, such as the Daughterless, Hairy-Enhancer of split, bHLH-PAS or bHLHZip subfamilies. The embryonic expression pattern of each of these new genes has been analyzed by in situ hybridization. By looking for closely structurally related motifs, we found two genes that represent likely orthologues of vertebrate Mnt and Mix. Together with previous reports, our data suggest that, similar to networks involved in neurogenesis and myogenesis, the network of Myc-related genes has been globally conserved throughout evolution. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 104

页数：6

共 18 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] A natural classification of the basic helix-loop-helix class of transcription factors [J].

Atchley, WR ;

Fitch, WM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5172-5176

[4] Recent improvements of the ProDom database of protein domain families [J].

Corpet, F ;

Gouzy, J ;

Kahn, D .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :263-267

[5] collier, a novel regulator of Drosophila head development, is expressed in a single mitotic domain [J].

Crozatier, M ;

Valle, D ;

Dubois, L ;

Ibnsouda, S ;

Vincent, A .

CURRENT BIOLOGY, 1996, 6 (06) :707-718

[6]

DAWSON SR, 1995, MOL CELL BIOL, V15, P6923

[7] Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates [J].

Fisher, AL ;

Caudy, M .

GENES & DEVELOPMENT, 1998, 12 (13) :1931-1940

[8] Vertebrate bHLH genes and the determination of neuronal fates [J].

Guillemot, F .

EXPERIMENTAL CELL RESEARCH, 1999, 253 (02) :357-364

[9]

Hassan BA, 2000, GENE DEV, V14, P1852

[10] Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating, rating cells and mediates repression at Myc binding sites [J].

Hurlin, PJ ;

Queva, C ;

Eisenman, RN .

GENES & DEVELOPMENT, 1997, 11 (01) :44-58

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