Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations

被引：104

作者：

Prockop, Darwin J. ^{[1
]}

Oh, Joo Youn ^{[2
]}

机构：

[1] Texas A&M Hlth Sci Ctr Coll Med Scott & White, Inst Regenerat Med, Temple, TX 76502 USA

[2] Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South Korea

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2012年 / 113卷 / 05期

关键词：

ADULT STEM; PROGENITOR CELL; MESENCHYMAL STEM CELL; MULTIPOTENT MESENCHYMAL STROMAL CELL; STEM CELL; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; INFLAMMATORY DAMAGE; INNATE IMMUNITY; MACROPHAGES; TSG-6; EXPRESSION; LUNG; ENGRAFTMENT; ACTIVATION;

D O I：

10.1002/jcb.24046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs. J. Cell. Biochem. 113: 14601469, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：1460 / 1469

页数：10

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