Activity of linezolid against anaerobic bacteria

被引：40

作者：

Behra-Miellet, J ^{[1
]}

Calvet, L ^{[1
]}

Dubreuil, L ^{[1
]}

机构：

[1] Fac Pharm, F-59006 Lille, France

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2003年 / 22卷 / 01期

关键词：

linezolid; oxazolidinones; anaerobes; MIC determination;

D O I：

10.1016/S0924-8579(03)00087-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Minimal inhibition concentrations (MICs) were determined for linezolid (LZD) and compared with those of reference antibiotics against 265 anaerobes. For the Bacteroides fragilis group, MIC range for LZD was 2-4 mg/l. Strains resistant to the other antibiotics were detected including one strain of B. ftagilis showing high level resistance to metronidazole (64 mg/l). LZD MIC50 was 4 mg/l for prevotella and 1 mg/l for fusobacteria. LZD MICs were < 1 mg/l for porphyromonas and veillonellae and :! 4 mg/l for all Gram-positive anaerobes. For all anacrobes, resistance rates were 1, 2.4, 9.8 and 17% for imipenem, amoxycillin-clavulanic acid, metronidazole and clindamycin, respectively. As no strains resistant to LZD were detected, this antibiotic seems a promising candidate to treat infections caused by anaerobes. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：28 / 34

页数：7

共 19 条

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