Cavin proteins: New players in the caveolae field

被引：75

作者：

Briand, Nolwenn ^{[1
,2
,3
]}

Dugail, Isabelle ^{[1
,2
,3
]}

Le Lay, Soazig ^{[1
,2
,3
]}

机构：

[1] Ctr Rech Cordeliers, INSERM, U872, F-75006 Paris, France

[2] Univ Paris 06, UMR S 872, F-75006 Paris, France

[3] Univ Paris 05, UMR S 872, F-75006 Paris, France

来源：

BIOCHIMIE | 2011年 / 93卷 / 01期

关键词：

Caveolin; Cavin; Caveolae; PTRF; SDPR; TRANSCRIPT-RELEASE FACTOR; COILED-COIL PROTEIN; POLYMERASE-I; GLUCOSE-INTOLERANCE; MUSCULAR-DYSTROPHY; MEMBRANE CURVATURE; BINDING PROTEIN; KNOCKOUT MICE; LIPID BODIES; FACTOR PTRF;

D O I：

10.1016/j.biochi.2010.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolae are specialized lipid microdomains, forming small invaginations in the plasma membrane, known to be implicated in multiple functions including lipid storage, cell signaling and endocytosis. Formation of these wide flask-shaped invaginations is dependent on the expression of a caveolar coat-protein, namely caveolin. Until now, the accepted paradigm was that caveolin was the sole and only structural protein of caveolae since its expression was necessary and sufficient to drive caveolae biogenesis. The recent characterizations of PTRF/cavin-1 and subsequently other cavin family members in caveolae formation have highlighted additional levels of complexity in the biogenesis of these plasma membrane invaginations. In this review, recent advances on the role of the different cavin family members in the regulation of caveolae structures as well as potential new functions will be discussed. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：71 / 77

页数：7

共 62 条

[1] Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes [J].