Novel concepts for improved communication between nerve cells and silicon electronic devices

被引：18

作者：

Huys, Roeland ^{[1
]}

Braeken, Dries ^{[1
]}

Van Meerbergen, Bart ^{[1
]}

Winters, Kurt ^{[1
]}

Eberle, Wolfgang ^{[1
]}

Loo, Josine ^{[1
]}

Tsvetanova, Diana ^{[1
]}

Chen, Chang ^{[1
]}

Severi, Simone ^{[1
]}

Yitzchaik, S. ^{[2
]}

Spira, M. ^{[2
]}

Shappir, J. ^{[2
]}

Callewaert, Geert ^{[3
]}

Borghs, Gustaaf ^{[1
]}

Bartic, Carmen ^{[1
]}

机构：

[1] IMEC, B-3001 Louvain, Belgium

[2] Hebrew Univ Jerusalem, IL-91904 Jerusalem, Israel

[3] Catholic Univ Louvain, Sub Fac Med, B-8500 Kortrijk, Belgium

来源：

SOLID-STATE ELECTRONICS | 2008年 / 52卷 / 04期

关键词：

neurons-on-chip; biosensors; biocompatibility; cytotoxicity; micro-nails; neurophysiology; neuronal recording; cardiomyocyte recording;

D O I：

10.1016/j.sse.2007.10.025

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Hybrid integration of living cells and electronic circuits oil a chip requires a high-density matrix of sensors and actuators. This matrix must be processable oil top of CMOS devices and must be bio-compatible in order to support living cells. Recent studies have shown that the use of nail structures combined with a phagocytosis-like event of the cell can be exploited to improve the electrical coupling between a cell and a sensor. In this paper, two CMOS-compatible fabrication methods for sub-micron nails will be presented. The biocompatibility and proof-of-concept is demonstrated by the culturing of PC 12 neuroblastoma cells. Electrical functionality is shown by simultaneous stimulation and recording of pig cardiomyocyte cells. Biocompatibility aspects for more demanding cortical cell cultures have been addressed in a preliminary assessment. (c) 2007 Published by Elsevier Ltd.

引用

页码：533 / 539

页数：7

共 16 条

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