50th anniversary of the word "Allosteric"

被引：65

作者：

Changeux, Jean-Pierre ^{[1
,2
]}

机构：

[1] Coll France, F-75231 Paris, France

[2] Inst Pasteur, Paris, France

来源：

PROTEIN SCIENCE | 2011年 / 20卷 / 07期

关键词：

allosteric; allostery; biochemistry; pharmacological literature; L-THREONINE DEAMINASE; ESCHERICHIA-COLI; ENZYME ACTION; FEEDBACK INHIBITION; ASPARTATE TRANSCARBAMYLASE; VALINE METABOLISM; PLAUSIBLE MODEL; ISOLEUCINE; PROTEINS; RECEPTOR;

D O I：

10.1002/pro.658

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A brief historical account on the origin and meaning of the word "allosteric'' is presented. The word was coined in an attempt to qualify the chemical mechanism of the feedback inhibition of bacterial enzymes by regulatory ligands. The data lead to the proposal that, at variance with the classical mechanism of mutual exclusion by steric hindrance, the inhibition takes place through an "allosteric'' interaction between "no overlapping'', stereospecifically distinct, sites for substrate and feedback inhibitor, mediated by a discrete reversible alteration of the molecular structure of the protein.

引用

页码：1119 / 1124

页数：6

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