Curved array photoacoustic tomographic system for small animal imaging

被引:104
作者
Gamelin, John [1 ]
Aguirre, Andres [1 ]
Maurudis, Anastasios [1 ]
Huang, Fei [1 ]
Castillo, Diego [1 ]
Wang, Lihong V. [2 ]
Zhu, Quing [1 ]
机构
[1] Univ Connecticut, Dept Elect Engn, Storrs, CT 06269 USA
[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA
关键词
photoacoustics; tomography; biomedical optics; medical imaging; point spread functions; ultrasonics;
D O I
10.1117/1.2907157
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25 mm radius. A 16-channel data-acquisition module and dedicated channel detection electronics enable capture of a 90-deg field-of-view image in less than 1 s and a complete 360-deg scan using sample rotation within 15 s. Measurements on cylindrical phantom targets demonstrate a resolution of better than 200 mu m and high-sensitivity detection of 580-mu m blood tubing to depths greater than 3 cm in a turbid medium with reduced scattering coefficient mu'(s) = 7.8 cm(-1). The system is used to systematically investigate the effects of target size, orientation, and geometry on tomographic imaging. As a demonstration of these effects and the system imaging capabilities, we present tomographic photoacoustic images of the brain vasculature of an ex vivo mouse with varying measurement aperture. For the first time, according to our knowledge, resolution of sub-200-mu m vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast. (C) 2008 Society of Photo-Optical Instrumentation Engineers.
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页数:10
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