Epilepsy Emergencies: Diagnosis and Management

被引:41
作者
Foreman, Brandon [2 ]
Hirsch, Lawrence J. [1 ]
机构
[1] Yale Univ, Sch Med, Div Epilepsy & EEG, New Haven, CT 06520 USA
[2] Columbia Univ, Med Ctr, Neurol Inst New York, Comprehens Epilepsy Ctr, New York, NY 10032 USA
关键词
Epilepsy; Seizures; Status epilepticus; Coma; Intensive care unit; Nonconvulsive seizures; Critical care; REFRACTORY STATUS EPILEPTICUS; NONCONVULSIVE STATUS EPILEPTICUS; TRAUMATIC BRAIN-INJURY; CONVULSIVE STATUS EPILEPTICUS; ADD-ON TREATMENT; ACUTE SYMPTOMATIC SEIZURE; INTENSIVE-CARE-UNIT; CRITICALLY-ILL; CONTINUOUS EEG; INTRAVENOUS LEVETIRACETAM;
D O I
10.1016/j.ncl.2011.09.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Seizures and status epilepticus are epilepsy emergencies with high morbidity and mortality. Early treatment is crucial, and the identification of an underlying etiology informs both continued treatment and prognosis. Many patients have underdiagnosed nonconvulsive seizures or nonconvulsive status epilepticus, particularly the comatose or critically ill. Timely EEG can be useful for diagnosis, management, optimizing treatment response, and determining prognosis in these patients. Refractory conditions can be quite complicated with limited evidence-based guidance, but treatment should not be restricted by nihilism even in the most prolonged cases, especially if there is not widespread irreversible brain injury.
引用
收藏
页码:11 / +
页数:32
相关论文
共 160 条
[51]  
FOUNTAIN NB, 1995, J CLIN NEUROPHYSIOL, V12, P326
[52]   Status epilepticus: Risk factors and complications [J].
Fountain, NB .
EPILEPSIA, 2000, 41 :S23-S30
[53]   Prolonged High-Dose Isoflurane for Refractory Status Epilepticus: Is It Safe? [J].
Fugate, Jennifer E. ;
Burns, Joseph D. ;
Wijdicks, Eelco F. M. ;
Warner, David O. ;
Jankowski, Christopher J. ;
Rabinstein, Alejandro A. .
ANESTHESIA AND ANALGESIA, 2010, 111 (06) :1520-1524
[54]   Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus [J].
Furtado Gouveia, Telma Luciana ;
Scorza, Fulvio Alexandre ;
Vieira Silva, Michele Juliana ;
Bandeira, Tatiane de Aquino ;
Perosa, Sandra Regina ;
Arganaraz, Gustavo Adolfo ;
Silva, Marcelo de Paula ;
Araujo, Thiago Rodrigues ;
Berzaghi Frangiotti, Maria Isabel ;
Amado, Debora ;
Cavalheiro, Esper Abrao ;
Silva, Jose Antonio, Jr. ;
Naffah-Mazzacoratti, Maria da Graca .
EPILEPSY & BEHAVIOR, 2011, 20 (01) :1-5
[55]  
Gastaut H, 1983, Adv Neurol, V34, P15
[56]   Saliva and serum lacosamide concentrations in patients with epilepsy [J].
Greenaway, Clare ;
Ratnaraj, Neville ;
Sander, Josemir W. ;
Patsalos, Philip N. .
EPILEPSIA, 2011, 52 (02) :258-263
[57]   Deep brain stimulation of the anterior nucleus of the thalamus: Effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus [J].
Hamani, Clement ;
Hodaie, Mojgan ;
Chiang, Jason ;
del Campo, Martin ;
Andrade, Danielle M. ;
Sherman, David ;
Mirski, Marek ;
Mello, Luiz E. ;
Lozano, Andres M. .
EPILEPSY RESEARCH, 2008, 78 (2-3) :117-123
[58]   Valproate-induced hyperammonemic encephalopathy in the presence of topiramate [J].
Hamer, HM ;
Knake, S ;
Schomburg, U ;
Rosenow, F .
NEUROLOGY, 2000, 54 (01) :230-232
[59]   First seizure definitions and worldwide incidence and mortality [J].
Hauser, W. Allen ;
Beghi, Ettore .
EPILEPSIA, 2008, 49 :8-12
[60]   INCIDENCE OF EPILEPSY AND UNPROVOKED SEIZURES IN ROCHESTER, MINNESOTA - 1935-1984 [J].
HAUSER, WA ;
ANNEGERS, JF ;
KURLAND, LT .
EPILEPSIA, 1993, 34 (03) :453-468