The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies

被引：34

作者：

Chistiakov, Dimitry A. ^{[1
,2
]}

Voronova, Natalia V. ^{[2
]}

Chistiakov, Pavel A. ^{[3
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15261 USA

[2] Natl Res Ctr GosNllgenet, Dept Mol Diagnost, Moscow 113545, Russia

[3] Endocrinol Res Ctr, Dept Diabetol, Moscow 117036, Russia

来源：

IMMUNOLOGY LETTERS | 2008年 / 118卷 / 01期

关键词：

autoimmunity; interleukin-2; receptor; susceptibility; type; 1; diabetes;

D O I：

10.1016/j.imlet.2008.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-2 (IL-2) plays an established role in T-cell regulation through binding to the high-affinity IL-2 receptor (IL-2R). The alpha-chain encoded by the IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type I diabetes (T1D). Significant association with T1D was also found in the region on chromosome 4q27 containing the IL2 gene and homologous to the susceptibility locus idd3 in non-obese diabetic (NOD) mice, an animal model for human T1D. Here we focus on the discussion of these new findings suggesting for a crucial role of IL-2/IL-2RA-mediated regulatory mechanisms in preventing T1D. The non-redundant role of IL-2 and its receptor in etiology of T1D could be particularly attributable to the regulation of CD4+ CD25+ regulatory T cells, whose function is critical in maintaining immune homeostasis. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

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