Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition

被引：837

作者：

Holmes, Katherine ^{[1
]}

Roberts, Owain Ll ^{[1
]}

Thomas, Angharad M. ^{[1
]}

Cross, Michael J. ^{[1
]}

机构：

[1] Univ Wales, NWCRF Inst, Sch Biol Sci, Coll Nat Sci, Bangor LL57 2UW, Gwynedd, Wales

来源：

CELLULAR SIGNALLING | 2007年 / 19卷 / 10期

基金：

英国医学研究理事会;

关键词：

VEGF; VEGFR-2; angiogenesis; endothelial; inhibitors; signal transduction; PROTEIN-KINASE-C; FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; KDR VEGF RECEPTOR-2; TYROSINE KINASE; ADAPTER PROTEIN; TUMOR ANGIOGENESIS; FACTOR GENE; PERMEABILITY FACTOR; DOMAIN RECEPTOR;

D O I：

10.1016/j.cellsig.2007.05.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis and lymphangiogenesis by binding to a number of receptors. VEGFR-I is required for the recruitment of haematopoietic stein cells and the migration of monocytes and macrophages, VEGFR-2 regulates vascular endothelial function and VEGFR-3 regulates lymphatic endothelial cell function. Over the last decade, considerable progress has been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response. Furthermore, therapeutic inhibition of VEGFR-2 action is now having an impact in the clinic for the treatment of a number of diseases. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：2003 / 2012

页数：10

共 113 条

[51] phospholipase C gamma-1 is require downstream of vascular endothelial growth factor during arterial development [J].

Lawson, ND ;

Mugford, JW ;

Diamond, BA ;

Weinstein, BM .

GENES & DEVELOPMENT, 2003, 17 (11) :1346-1351

[52] Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors [J].

Lee, S ;

Jilani, SM ;

Nikolova, GV ;

Carpizo, D ;

Iruela-Arispe, ML .

JOURNAL OF CELL BIOLOGY, 2005, 169 (04) :681-691

[53] KDR (VEGF receptor 2) is the major mediator for the hypotensive effect of VEGF [J].

Li, B ;

Ogasawara, AK ;

Yang, RH ;

Wei, W ;

He, GW ;

Zioncheck, TF ;

Bunting, S ;

de Vos, AM ;

Jin, HK .

HYPERTENSION, 2002, 39 (06) :1095-1100

[54] Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice [J].

Liao, HJ ;

Kume, T ;

McKay, C ;

Xu, MJ ;

Ihle, JN ;

Carpenter, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9335-9341

[55] Vascular endothelial growth factor-regulated gene expression in endothelial cells - KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1 [J].

Liu, D ;

Jia, HY ;

Holmes, DIR ;

Stannard, A ;

Zachary, I .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (11) :2002-2007

[56] HYPOXIA REGULATES VASCULAR ENDOTHELIAL GROWTH-FACTOR GENE-EXPRESSION IN ENDOTHELIAL-CELLS - IDENTIFICATION OF A 5'-ENHANCER [J].

LIU, YX ;

COX, SR ;

MORITA, T ;

KOUREMBANAS, S .

CIRCULATION RESEARCH, 1995, 77 (03) :638-643

[57] HOMOLOGS OF VASCULAR ENDOTHELIAL GROWTH-FACTOR ARE ENCODED BY THE POXVIRUS ORF VIRUS [J].

LYTTLE, DJ ;

FRASER, KM ;

FLEMING, SB ;

MERCER, AA ;

ROBINSON, AJ .

JOURNAL OF VIROLOGY, 1994, 68 (01) :84-92

[58]

Mason JC, 2001, ARTHRITIS RHEUM, V44, P138, DOI 10.1002/1529-0131(200101)44:1<138::AID-ANR18>3.0.CO

[59]

2-G

[60] VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis [J].

Matsumoto, T ;

Bohman, S ;

Dixelius, J ;

Berge, T ;

Dimberg, A ;

Magnusson, P ;

Wang, L ;

Wikner, C ;

Qi, JH ;

Wernstedt, C ;

Wu, J ;

Bruheim, S ;

Mugishima, H ;

Mukhopadhyay, D ;

Spurkland, A ;

Claesson-Welsh, L .

EMBO JOURNAL, 2005, 24 (13) :2342-2353

← 1 2 3 4 5 6 7 8 9 10 →