Inflammasome-IL-1-Th17 response in allergic lung inflammation

被引：128

作者：

Besnard, Anne-Gaelle ^{[1
,2
]}

Togbe, Dieudonnee ^{[1
,2
,3
]}

Couillin, Isabelle ^{[1
,2
]}

Tan, Zoming ^{[1
,2
]}

Zheng, Song Guo ^{[4
]}

Erard, Francois ^{[1
,2
]}

Le Bert, Marc ^{[1
,2
]}

Quesniaux, Valerie ^{[1
,2
]}

Ryffel, Bernhard ^{[1
,2
,5
]}

机构：

[1] Univ Orleans, Orleans, France

[2] CNRS UMR6218, Orleans, France

[3] Artimmune SAS, Ctr Innovat, Orleans, France

[4] Univ So Calif, Div Rheumatol & Immunol, Dept Med, Los Angeles, CA 90033 USA

[5] Univ Cape Town, IIDMM, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2012年 / 4卷 / 01期

关键词：

asthma; NLRP3; inflammasome; IL-1; Th17; cells; IL-17; IL-22; EOSINOPHILIC AIRWAY INFLAMMATION; ARYL-HYDROCARBON RECEPTOR; MUCOSAL HOST-DEFENSE; DELTA T-CELLS; TH17; CELLS; DENDRITIC CELLS; URIC-ACID; NEUTROPHIL RECRUITMENT; EPITHELIAL-CELLS; INDUCIBLE FACTOR;

D O I：

10.1093/jmcb/mjr042

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Allergic asthma has increased dramatically in prevalence and severity over the last three decades. Both clinical and experimental data support an important role of Th2 cell response in the allergic response. Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1 beta to mature IL-1 beta through caspase-1. The production of pro-IL-1 beta requires a toll-like receptor (TLR) 4 signal which is provided by the allergen. IL-1 beta creates a pro-inflammatory milieu with the production of IL-6 and chemokines which mobilize neutrophils and enhance Th17 cell differentiation in the lung. Here, we review our results showing that NLRP3 inflammasome activation is required to develop allergic airway inflammation in mice and that IL-17 and IL-22 production by Th17 cells plays a critical role in established asthma. Therefore, inflammasome activation leading to IL-1 beta production contributes to the control of allergic asthma by enhancing Th17 cell differentiation.

引用

页码：3 / 10

页数：8

共 95 条

[1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].