A new method for the solution and solid phase synthesis of chiral beta-sulfonopeptides under mild conditions

被引：67

作者：

Gude, M

Piarulli, U

Potenza, D

Salom, B

Gennari, C

机构：

[1] CNR,CTR SOST ORG NAT,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

[2] UNIV MILAN,FAC SCI 2,IST SCI MAT FIS & CHIM,I-22100 COMO,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01963-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral beta-sulfonopeptides were synthesized both in solution and in the solid phase using the sulfonyl chlorides derived from enantiomerically pure 2-substituted taurines under mild coupling conditions [cat. 4-dimethylaminopyridine (DMAP) and excess methyl trimethylsilyl dimethylketene acetal (MTDA) as a proton trap]. Copyright (C) 1996 Elsevier Science Ltd

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页码：8589 / 8592

页数：4

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