The neuronal Kv4 channel complex

被引：57

作者：

Covarrubias, Manuel ^{[1
]}

Bhattacharji, Aditya ^{[1
]}

De Santiago-Castillo, Jose A. ^{[1
]}

Dougherty, Kevin ^{[1
]}

Kaulin, Yuri A. ^{[1
]}

Na-Phuket, Thanawath Ratanadilok ^{[1
]}

Wang, Guangyu ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

来源：

NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 08期

关键词：

voltage-gated potassium channel; gating; inactivation; auxiliary beta subunits; A-type potassium current; T1; domain;

D O I：

10.1007/s11064-008-9650-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kv4 channel complexes mediate the neuronal somatodendritic A-type K+ current (I-SA), which plays pivotal roles in dendritic signal integration. These complexes are composed of pore-forming voltage-gated alpha-subunits (Shal/Kv4) and at least two classes of auxiliary beta-subunits: KChIPs (K+-Channel-Interacting-Proteins) and DPLPs (Dipeptidyl-Peptidase-Like-Proteins). Here, we review our investigations of Kv4 gating mechanisms and functional remodeling by specific auxiliary beta-subunits. Namely, we have concluded that: (1) the Kv4 channel complex employs novel alternative mechanisms of closed-state inactivation; (2) the intracellular Zn2+ site in the T1 domain undergoes a conformational change tightly coupled to voltage-dependent gating and is targeted by nitrosative modulation; and (3) discrete and specific interactions mediate the effects of KChIPs and DPLPs on activation, inactivation and permeation of Kv4 channels. These studies are shedding new light on the molecular bases of I-SA function and regulation.

引用

页码：1558 / 1567

页数：10

共 136 条

[1] A-type potassium currents in smooth muscle [J].