Assembling amperometric biosensors for clinical diagnostics

被引：94

作者：

Soledad Belluzo, Maria ^{[1
]}

Elida Ribone, Maria ^{[1
]}

Marina Lagier, Claudia ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Dept Analyt Chem, RA-2000 Rosario, Santa Fe, Argentina

来源：

SENSORS | 2008年 / 8卷 / 03期

关键词：

biosensor; electrochemical; amperometric; clinical diagnosis;

D O I：

10.3390/s8031366

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Clinical diagnosis and disease prevention routinely require the assessment of species determined by chemical analysis. Biosensor technology offers several benefits over conventional diagnostic analysis. They include simplicity of use, specificity for the target analyte, speed to arise to a result, capability for continuous monitoring and multiplexing, together with the potentiality of coupling to low-cost, portable instrumentation. This work focuses on the basic lines of decisions when designing electron-transfer-based biosensors for clinical analysis, with emphasis on the strategies currently used to improve the device performance, the present status of amperometric electrodes for biomedicine, and the trends and challenges envisaged for the near future.

引用

页码：1366 / 1399

页数：34

共 234 条

[1] Genosensor on gold films with enzymatic electrochemical detection of a SARS virus sequence [J].

Abad-Valle, P ;

Fernandez-Abedul, MT ;

Costa-García, A .

BIOSENSORS & BIOELECTRONICS, 2005, 20 (11) :2251-2260

[2] Study of metallothionein modified electrode surface behavior in the presence of heavy metal ions-biosensor [J].

Adam, V ;

Petrlova, J ;

Potesil, D ;

Zehnalek, J ;

Sures, B ;

Trnkova, L ;

Jelen, F ;

Kizek, R .

ELECTROANALYSIS, 2005, 17 (18) :1649-1657

[3] THE USE AND CLINICAL IMPORTANCE OF A SUBSTRATE-SPECIFIC ELECTRODE FOR RAPID-DETERMINATION OF BLOOD LACTATE CONCENTRATIONS [J].

ADUEN, J ;

BERNSTEIN, WK ;

KHASTGIR, T ;

MILLER, JA ;

KERZNER, R ;

BHATIANI, A ;

LUSTGARTEN, J ;

BASSIN, AS ;

DAVISON, L ;

CHERNOW, B .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (21) :1678-1685

[4] Design, construction, and evaluation of a specific chimeric antigen to diagnose chagasic infection [J].

Aguirre, Sebastian ;

Silber, Ariel M. ;

Brito, Maria Edileuza F. ;

Ribone, Maria E. ;

Lagier, Claudia M. ;

Marcipar, Ivan S. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (10) :3768-3774

[5] ENZYME IMMUNOSENSOR .3. AMPEROMETRIC DETERMINATION OF HUMAN CHORIONIC-GONADOTROPIN BY MEMBRANE-BOUND ANTIBODY [J].

AIZAWA, M ;

MORIOKA, A ;

SUZUKI, S ;

NAGAMURA, Y .

ANALYTICAL BIOCHEMISTRY, 1979, 94 (01) :22-28

[6] Design of molecular wires based on supramolecular structures for application in glucose biosensors [J].

Alves, Wendel A. ;

Fiorito, Pablo A. ;

de Torresi, Susana I. Cordoba ;

Torresi, Roberto M. .

BIOSENSORS & BIOELECTRONICS, 2006, 22 (02) :298-305

[7] FLOW-INJECTION ANALYSIS OF L-LACTATE WITH ENZYME AMPLIFICATION AND AMPEROMETRIC DETECTION [J].

ASOUZU, MU ;

NONIDEZ, WK ;

HO, MH .

ANALYTICAL CHEMISTRY, 1990, 62 (07) :708-712

[8]

Baker BR, 2006, J AM CHEM SOC, V128, P3138, DOI 10.1021/ja056957p

[9]

BARRETTINO D, 2006, ISCAS 2006 P IEEE IN, V2006, P4359

[10] Covalent attachment of osmium complexes to glucose oxidase and the application of the resulting modified enzyme in an enzyme switch responsive to glucose [J].

Battaglini, F ;

Bartlett, PN ;

Wang, JH .

ANALYTICAL CHEMISTRY, 2000, 72 (03) :502-509

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