Telomerase Inhibitors as Novel Antitumor Drugs

被引：7

作者：

Glukhov, A. I. ^{[1
,2
]}

Svinareva, L. V. ^{[2
,3
]}

Severin, S. E. ^{[1
,2
]}

Shvets, V. I. ^{[3
]}

机构：

[1] IM Sechenov Med Acad, Moscow 119435, Russia

[2] Moscow Res Inst Med Ecol, Moscow 117149, Russia

[3] Lomonosov Moscow State Acad Fine Chem Technol, Moscow 119571, Russia

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2011年 / 47卷 / 07期

关键词：

antisense therapy; immortalization; G-quadruplex; ribozyme; RNA interference; telomerase activity; HUMAN CANCER-CELLS; HAMMERHEAD RIBOZYME; RNA COMPONENT; IN-VITRO; ANTISENSE OLIGONUCLEOTIDES; MESSENGER-RNA; G-QUADRUPLEX; GROWTH; HTERT; INTERFERENCE;

D O I：

10.1134/S0003683811070039

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Telomerase activity is detected in most types of human tumors, but it is almost undetectable in normal somatic cells; therefore, telomerase is a promising therapeutic target. The present review describes various approaches to telomerase inhibition, namely, antisense therapy, RNA interference, and the use of ribozymes and agents interacting with the telomeric G-quadruplex. The use of these compounds in clinical research is analyzed in the review.

引用

页码：655 / 660

页数：6

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