Towards a molecular approach to gastric cancer management

被引:14
作者
Boussioutas, A
Taupin, D
机构
[1] Canberra Hosp, Gastroenterol Unit, Garran, ACT 2605, Australia
[2] Peter MacCallum Canc Inst, Melbourne, Vic 3000, Australia
关键词
cDNA microarray; expression analysis; gastric cancer; tumour array; tumour marker;
D O I
10.1046/j.1445-5994.2001.00057.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gastric cancer is a leading cause of cancer death worldwide. Most patients with gastric cancer present with locally advanced and incurable disease, and overall survival is poor. Considerable research efforts towards the epidemiology and pathogenesis of gastric cancer have not been translated into treatment success. We discuss current concepts of the pathogenesis of gastric cancer and how recent research advances, in particular global gene expression strategies, may improve this understanding, and suggest a framework wherein these approaches may be used.
引用
收藏
页码:296 / 303
页数:8
相关论文
共 80 条
[11]   Hormone therapy failure in human prostate cancer:: Analysis by complementary DNA and issue microarrays [J].
Bubendorf, L ;
Kolmer, M ;
Kononen, J ;
Koivisto, P ;
Mousses, S ;
Chen, YD ;
Mahlamäki, E ;
Schraml, P ;
Moch, H ;
Willi, N ;
Elkahloun, AG ;
Pretlow, TG ;
Gasser, TC ;
Mihatsch, MJ ;
Sauter, G ;
Kallioniemi, OP .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (20) :1758-1764
[12]   A CASE-CONTROL STUDY OF GASTRIC-CANCER AND DIET IN ITALY .2. ASSOCIATION WITH NUTRIENTS [J].
BUIATTI, E ;
PALLI, D ;
DECARLI, A ;
AMADORI, D ;
AVELLINI, C ;
BIANCHI, S ;
BONAGURI, C ;
CIPRIANI, F ;
COCCO, P ;
GIACOSA, A ;
MARUBINI, E ;
MINACCI, C ;
PUNTONI, R ;
RUSSO, A ;
VINDIGNI, C ;
FRAUMENI, JF ;
BLOT, WJ .
INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (05) :896-901
[13]  
Chabner BA, 1998, CANCER RES, V58, P4211
[14]   The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis [J].
Chung, DC .
GASTROENTEROLOGY, 2000, 119 (03) :854-865
[15]  
Ciardiello F, 2000, CLIN CANCER RES, V6, P2053
[16]   Occupational risk factors for gastric cancer: An overview [J].
Cocco, P ;
Ward, MH ;
Buiatti, E .
EPIDEMIOLOGIC REVIEWS, 1996, 18 (02) :218-234
[17]   STOMACH-CANCER AND FOOD STORAGE [J].
COGGON, D ;
BARKER, DJP ;
COLE, RB ;
NELSON, M .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (15) :1178-1182
[18]   PATHOLOGY OF GASTRIC CARCINOMA IN JAPANESE POPULATIONS - COMPARISONS BETWEEN MIYAGI PREFECTURE, JAPAN, AND HAWAII [J].
CORREA, P ;
SASANO, N ;
STEMMERMANN, GN ;
HAENSZEL, W .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (05) :1449-1459
[19]   Helicobacter pylori factors associated with disease [J].
Cover, TL ;
Blaser, MJ .
GASTROENTEROLOGY, 1999, 117 (01) :257-260
[20]   The role of chemotherapy in the management of gastric cancer [J].
De Vivo, R ;
Pignata, S ;
Palaia, R ;
Parisi, V ;
Daniele, B .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 2000, 30 (04) :364-371