Towards a molecular approach to gastric cancer management

被引：14

作者：

Boussioutas, A

Taupin, D

机构：

[1] Canberra Hosp, Gastroenterol Unit, Garran, ACT 2605, Australia

[2] Peter MacCallum Canc Inst, Melbourne, Vic 3000, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2001年 / 31卷 / 05期

关键词：

cDNA microarray; expression analysis; gastric cancer; tumour array; tumour marker;

D O I：

10.1046/j.1445-5994.2001.00057.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gastric cancer is a leading cause of cancer death worldwide. Most patients with gastric cancer present with locally advanced and incurable disease, and overall survival is poor. Considerable research efforts towards the epidemiology and pathogenesis of gastric cancer have not been translated into treatment success. We discuss current concepts of the pathogenesis of gastric cancer and how recent research advances, in particular global gene expression strategies, may improve this understanding, and suggest a framework wherein these approaches may be used.

引用

收藏

页码：296 / 303

页数：8

相关论文

共 80 条

[61] Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer [J].

Richards, FM ;

McKee, SA ;

Rajpar, MH ;

Cole, TRP ;

Evans, DGR ;

Jankowski, JA ;

McKeown, C ;

Sanders, DSA ;

Maher, ER .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :607-610

[62] Systematic variation in gene expression patterns in human cancer cell lines [J].

Ross, DT ;

Scherf, U ;

Eisen, MB ;

Perou, CM ;

Rees, C ;

Spellman, P ;

Iyer, V ;

Jeffrey, SS ;

Van de Rijn, M ;

Waltham, M ;

Pergamenschikov, A ;

Lee, JCE ;

Lashkari, D ;

Shalon, D ;

Myers, TG ;

Weinstein, JN ;

Botstein, D ;

Brown, PO .

NATURE GENETICS, 2000, 24 (03) :227-235

[63] TUMOR SUPPRESSOR GENES - THE PUZZLE AND THE PROMISE [J].

SAGER, R .

SCIENCE, 1989, 246 (4936) :1406-1412

[64] Expression genetics in cancer: Shifting the focus from DNA to RNA [J].

Sager, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (03) :952-955

[65]

Sasaki I, 1999, CANCER, V85, P1719, DOI 10.1002/(SICI)1097-0142(19990415)85:8<1719::AID-CNCR11>3.3.CO

[66]

2-M

[67] Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase [J].

Schindler, T ;

Bornmann, W ;

Pellicena, P ;

Miller, WT ;

Clarkson, B ;

Kuriyan, J .

SCIENCE, 2000, 289 (5486) :1938-1942

[68]

Schraml P, 1999, CLIN CANCER RES, V5, P1966

[69] Pieces of the puzzle: expressed sequence tags and the catalog of human genes [J].

Schuler, GD .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (10) :694-698

[70] ROLE OF LABORATORY CHEMOSENSITIVITY TESTING IN THE SELECTION OF CANCER-CHEMOTHERAPY FOR INDIVIDUAL PATIENTS [J].

SELBY, PJ ;

RAGHAVAN, D .

JOURNAL OF CLINICAL PATHOLOGY, 1981, 34 (05) :455-463

← 1 2 3 4 5 6 7 8 →