Dynamics of cAMP-dependent protein kinase

被引：327

作者：

Johnson, DA

Akamine, P

Radzio-Andzelm, E

Madhusudan

Taylor, SS

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000226k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dynamics of cAMP-dependent protein kinase which provided a mechanism for cells to respond to external stimuli were studied. NMR spectroscopy were employed to monitor the dynamics of the protein and also provided high-resolution information of proteins in the solutions. The results showed that the correct assembly of the active kinase depended on the critical addition of a phosphate.

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页码：2243 / 2270

页数：28

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