G-quadruplex RNA structure as a signal for neurite mRNA targeting

被引：191

作者：

Subramanian, Murugan ^{[1
]}

Rage, Florence ^{[2
]}

Tabet, Ricardos ^{[1
]}

Flatter, Eric ^{[1
]}

Mandel, Jean-Louis ^{[1
]}

Moine, Herve ^{[1
]}

机构：

[1] Strasbourg Univ, Coll France, IGBMC, CNRS,UMR7104,INSERM,U596, F-67404 Illkirch Graffenstaden, France

[2] Inst Genet Mol Montpellier, UMR5535, F-34293 Montpellier, France

来源：

EMBO REPORTS | 2011年 / 12卷 / 07期

关键词：

mRNA trafficking; Guanine-quadruplex; PSD-95; CaMKIIa; FMRP; MENTAL-RETARDATION PROTEIN; RECEPTOR-DEPENDENT TRANSLATION; SYNAPTIC PLASTICITY; G-QUARTET; LOCALIZATION; TRANSPORT; SEQUENCES; ALPHA; FMRP;

D O I：

10.1038/embor.2011.76

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeting of messenger RNAs (mRNAs) in neuron processes relies on cis-acting regulatory elements, the nature of which is poorly understood. Here, we report that approximately 30% of the best-known dendritic mRNAs contain a guanine (G)-quadruplex consensus in their 30-untranslated region. Among these mRNAs, we show by using RNA structure probing that a G-quadruplex is present in the mRNAs of two key postsynaptic proteins: PSD-95 and CaMKIIa. The G-quadruplex structure is necessary and sufficient for the potent and fast localization of mRNAs in cortical neurites and this occurs in a metabotropic glutamate receptor-responsive manner. Thus, G-quadruplex seems to be a common neurite localization signal.

引用

页码：697 / 704

页数：8

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