Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats

被引:43
作者
Azuma, K [1 ]
Ippoushi, K
Ito, H
Horie, H
Terao, J
机构
[1] Natl Agr Res Org, Natl Inst Vegetable & Tea Sci, Ano, Mie 5142392, Japan
[2] Univ Tokushima, Sch Med, Dept Nutr, Tokushima 7708503, Japan
关键词
onion; quercetin metabolite; plasma; lipid; emulsifier;
D O I
10.1271/bbb.67.2548
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of co-ingested lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats were investigated. Plasma extracts of rats that had been fed onion-containing diets for one and two weeks were analyzed by HPLC with electrochemical detection after a treatment with sulfatase/beta-glucuronidase. Almost all of the quercetin metabolites in the plasma were sulfate/glucuronide conjugates of quercetin and isorhamnetin. More than 4.6% (w/w) of soybean oil in the diets significantly enhanced the accumulation of quercetin metabolites in the plasma. Fish oil and beef tallow increased this to an extent similar to that with soybean oil, and lecithin was more effective than the other three lipids. Two emulsifiers, sodium caseinate and sucrose fatty acid ester, also showed an enhancing effect on the accumulation of quercetin metabolites. These results indicate that co-ingested lipids and emulsifiers could enhance the bioavailability of quercetin glucosides in onion.
引用
收藏
页码:2548 / 2555
页数:8
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