Cutting edge:: Priming of NK cells by IL-18

被引：253

作者：

Chaix, Julie ^{[1
]}

Tessmer, Marlowe S. ^{[2
]}

Hoebe, Kasper ^{[3
]}

Fuseri, Nicolas ^{[1
]}

Ryffel, Bernhard ^{[4
,5
]}

Dalod, Marc ^{[1
]}

Alexopoulou, Lena ^{[1
]}

Beutler, Bruce ^{[6
]}

Brossay, Laurent ^{[2
]}

Vivier, Eric ^{[1
,7
]}

Walzer, Thierry ^{[1
]}

机构：

[1] Univ Aix Marseille 2, CNRS, INSERM, Ctr Immunol Marseille Luminy,UMR 6102, F-13288 Marseille, France

[2] Brown Univ, Div Biol & Med, Dept Mol Microbiol & Immunol, Providence, RI 02912 USA

[3] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp, Res Fdn,Div Mol Immunol, Cincinnati, OH 45229 USA

[4] Univ Orleans, Orleans, France

[5] CNRS, UMR 6218, F-45071 Orleans, France

[6] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[7] Hop Marseille, Hop Concept, Marseille, France

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 03期

关键词：

D O I：

10.4049/jimmunol.181.3.1627

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence suggests that NK cells require priming to display full effector activity. In this study, we demonstrate that IL-18 contributed to this phenomenon. IL-18 signaling-deficient NK cells were found to be unable to secrete IFN-gamma in response to ex vivo stimulation with IL-12. This was not due to a costimulatory role of IL-18, because blocking IL-18 signaling during the ex vivo stimulation with IL-12 did not alter IFN-gamma production by wild-type NK cells. Rather, we demonstrate that IL-18 primes NK cells in vivo to produce IFN-gamma upon subsequent stimulation with IL-12. Importantly, IL-12-induced IFN-gamma transcription by NK cells was comparable in IL-18 signaling-deficient and -sufficient NK cells. This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines.

引用

页码：1627 / 1631

页数：5

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