LIPID RAFTS, CAVEOLAE, AND THEIR ENDOCYTOSIS

被引：285

作者：

Lajoie, Patrick ^{[1
]}

Nabi, Ivan R. ^{[2
]}

机构：

[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY USA

[2] Univ British Columbia, Dept Cellular & Physiol Sci, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 282 | 2010年 / 282卷

关键词：

Caveolae; Lipid rafts; Endocytosis; Caveolin; Actin; Signaling; GPI-ANCHORED PROTEINS; GROWTH-FACTOR RECEPTOR; CLATHRIN-INDEPENDENT ENDOCYTOSIS; PLASMA-MEMBRANE MICRODOMAINS; RESONANCE ENERGY-TRANSFER; AUTOCRINE MOTILITY FACTOR; FOCAL ADHESION DYNAMICS; TOXIN-B-SUBUNIT; T-CELL-RECEPTOR; MEDIATED ENDOCYTOSIS;

D O I：

10.1016/S1937-6448(10)82003-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids that are involved in the lateral compartmentalization of molecules at the cell surface. Internalization of ligands and receptors by these domains occurs via a process defined as raft-dependent endocytosis. Caveolae are caveolin-1-enriched smooth invaginations of the plasma membrane that form a subdomain of lipid rafts. Endocytosis of rafts, including caveolar but also noncaveolar dynamin-dependent and dynamin-independent pathways, is characterized by its cholesterol sensitivity and clathrin-independence. In this review we will characterize lipid rafts and caveolae, their endocytosis and its regulation by the actin cytoskeleton, caveolin-1, dynamin, and cholesterol.

引用

页码：135 / 163

页数：29

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