Serum Concentrations of Myostatin and Myostatin-Interacting Proteins Do Not Differ Between Young and Sarcopenic Elderly Men

被引：83

作者：

Ratkevicius, A.

Joyson, A.

Selmer, I. ^{[2
]}

Dhanani, T. ^{[2
]}

Grierson, C. ^{[2
]}

Tommasi, A. M. ^{[2
]}

DeVries, A. ^{[2
]}

Rauchhaus, P. ^{[2
]}

Crowther, D. ^{[2
]}

Alesci, S. ^{[3
]}

Yaworsky, P. ^{[3
]}

Gilbert, F. ^{[4
]}

Redpath, T. W. ^{[4
]}

Brady, J. ^{[2
]}

Fearon, K. C. H. ^{[5
]}

Reid, D. M. ^{[6
]}

Greig, C. A. ^{[5
]}

Wackerhage, H. ^{[1
]}

机构：

[1] Univ Aberdeen, Bone & Musculoskeletal Mol Exercise Physiol Grp, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

[2] Translat Med Res Collaborat Core Lab, Dundee, Scotland

[3] Pfizer, Cambridge, MA USA

[4] Univ Aberdeen, Biomed Imaging Ctr, Sch Med, Aberdeen AB25 2ZD, Scotland

[5] Univ Edinburgh, Sch Clin Sci & Community Hlth, Edinburgh EH8 9YL, Midlothian, Scotland

[6] Univ Aberdeen, Sch Med, Aberdeen AB25 2ZD, Scotland

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2011年 / 66卷 / 06期

关键词：

Sarcopenia; Myostatin; GROWTH-FACTOR-I; MUSCLE MASS; OLDER-ADULTS; HYPERTROPHY; RESISTANCE; STRENGTH; HEALTH; INTERLEUKIN-6; EXERCISE; FATIGUE;

D O I：

10.1093/gerona/glr025

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-I, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imagine measurement) were significantly higher in young (22 +/- 2 years; 266 +/- 54 N/m; 8,686 +/- 1,154 mm(2)) than in mildly sarcopenic (69 +/- 3 years; 183 +/- 17 N/m; 6,621 +/- 718 mm(2)) and severely sarcopenic men (76 +/- 6 years: 127 +/- 23 N/m; 5,846 +/- 591 mm(2)), respectively (p <=.01 for all comparisons). There was a trend (p =.06) toward higher FLRG in young (20 +/- 8 ng/mL) than in mildly (15 +/- 6 ng/mL) and severely sarcopenic men (17 +/- 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor alpha, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p <.001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

引用

页码：620 / 626

页数：7

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