An enantio- and stereocontrolled synthesis of (-)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction

被引:133
作者
Iwabuchi, Y [1 ]
Furukawa, M [1 ]
Esumi, T [1 ]
Hatakeyama, S [1 ]
机构
[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan
关键词
D O I
10.1039/b106471c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new enantiocontrolled synthesis of a potent immunosuppressant (-)-mycestericin E has been accomplished by using cinchona alkaloid-catalyzed asymmetric Baylis-Hillman reaction of an aldehyde with 1,1,1,3,3,3-hexafluoroisopropyl acrylate and Lewis acid-promoted cyclisation of an epoxytrichloroacetimidate as the key steps.
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页码:2030 / 2031
页数:2
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