Fungal metabolites. 22. Determination of absolute configuration and biological activity of new immunosuppressants, mycestericins D, E, F and G

被引：59

作者：

Fujita, T

Hamamichi, N

Kiuchi, M

Matsuzaki, T

Kitao, Y

Inoue, K

Hirose, R

Yoneta, M

Sasaki, S

Chiba, K

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, SAKYO KU, KYOTO 60601, JAPAN

[2] TAITO CO LTD, RES LAB, NAGATA KU, KOBE 653, JAPAN

[3] YOSHITOMI PHARMACEUT IND LTD, RES LABS, IRUMA, SAITAMA 358, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.846

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mycestericins D, E, F and G were isolated from the culture broth of Mycelia sterilia ATCC 20349 as potent immunosuppressants. Mycestericins F and G were identical with dihydromycestericins D and E, respectively. Their absolute configurations were determined by use of the modified MOSHER's method and by comparison of the CD spectra of their benzoate derivatives with those of synthetic analogs. Mycestericins D, E, F and G suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction.

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页码：846 / 853

页数：8

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