RNAi the natural way

被引：66

作者：

Cullen, BR ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Ctr Virol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 11期

关键词：

D O I：

10.1038/ng1105-1163

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although RNA interference has become a useful genetic technique, effective and stable knock-down of vertebrate genes remains a challenge, especially in vivo. A new approach, which uses RNA polymerase II to generate small interfering RNAs, not only seems to be more effective than previous approaches but also allows tightly regulated RNA interference in culture and in vivo.

引用

收藏

页码：1163 / 1165

页数：4

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