Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

被引：630

作者：

Mukhtar, M. Shahid ^{[3
]}

Carvunis, Anne-Ruxandra ^{[1
,2
,4
,5
,6
]}

Dreze, Matija ^{[1
,2
,4
,7
]}

Epple, Petra ^{[3
]}

Steinbrenner, Jens ^{[8
]}

Moore, Jonathan ^{[9
]}

Tasan, Murat ^{[10
]}

Galli, Mary ^{[11
]}

Hao, Tong ^{[1
,2
,4
]}

Nishimura, Marc T. ^{[3
]}

Pevzner, Samuel J. ^{[1
,2
,4
,12
]}

Donovan, Susan E. ^{[8
]}

Ghamsari, Lila ^{[1
,2
,4
]}

Santhanam, Balaji ^{[1
,2
,4
]}

Romero, Viviana ^{[1
,2
,4
]}

Poulin, Matthew M. ^{[1
,2
,4
]}

Gebreab, Fana ^{[1
,2
,4
]}

Gutierrez, Bryan J. ^{[1
,2
,4
]}

Tam, Stanley ^{[1
,2
,4
]}

Monachello, Dario ^{[1
,2
,13
]}

Boxem, Mike ^{[14
]}

Harbort, Christopher J. ^{[3
]}

McDonald, Nathan ^{[3
]}

Gai, Lantian ^{[11
]}

Chen, Huaming ^{[11
]}

He, Yijian ^{[3
]}

Vandenhaute, Jean ^{[7
]}

Roth, Frederick P. ^{[1
,2
,15
]}

Hill, David E. ^{[1
,2
,4
]}

Ecker, Joseph R. ^{[11
,16
]}

Vidal, Marc ^{[1
,2
,4
]}

Beynon, Jim

Braun, Pascal ^{[1
,2
,4
]}

Dangl, Jeffery L. ^{[3
,17
,18
,19
]}

机构：

[1] Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[3] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[5] CNRS, Computat & Math Biol Grp, TIMC IMAG, UMR5525, F-38706 La Tronche, France

[6] Univ Grenoble, Fac Med, F-38706 La Tronche, France

[7] Fac Univ Notre Dame Paix, Unite Rech Biol Mol, B-5000 Namur, Wallonia Brusse, Belgium

[8] Univ Warwick, Sch Life Sci, Wellesbourne CV35, Warwick, England

[9] Univ Warwick, Warwick Syst Biol Ctr, Coventry CV4 7AL, W Midlands, England

[10] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[11] Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA

[12] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[13] Univ Evry Val Essonne European Res Lab UEVE ERL, CNRS, Inst Natl Rech Agron INRA, Unite Mixte Rech Genom Vegetale URGV,UM, F-91057 Evry, France

[14] Univ Utrecht, NL-3584 CH Utrecht, Netherlands

[15] Harvard Univ, Dept Biol Chem & Mol Pharmacol, Sch Med, Boston, MA 02115 USA

[16] Salk Inst Biol Studies, Biol Lab, La Jolla, CA 92037 USA

[17] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

[18] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

[19] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2011年 / 333卷 / 6042期

基金：

英国生物技术与生命科学研究理事会; 美国国家科学基金会;

关键词：

DISEASE RESISTANCE; ARMS-RACE; ARABIDOPSIS; VIRUS;

D O I：

10.1126/science.1203659

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and similar to 8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.

引用

页码：596 / 601

页数：6

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