A multi-component coupling approach to benzo[b]furans and indoles

被引:59
作者
Chaplin, JH [1 ]
Flynn, BL [1 ]
机构
[1] Australian Natl Univ, The Faculties, Dept Chem, Canberra, ACT 0200, Australia
关键词
D O I
10.1039/b104624c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A single step access to multiply substituted benzo[b]furans and indoles has been developed.
引用
收藏
页码:1594 / 1595
页数:2
相关论文
共 10 条
[1]  
Arcadi A, 1999, EUR J ORG CHEM, V1999, P1137
[2]   2-SUBSTITUTED-3-ACYLINDOLES THROUGH THE PALLADIUM-CATALYZED CARBONYLATIVE CYCLIZATION OF 2-ALKYNYLTRIFLUOROACETANILIDES WITH ARYL HALIDES AND VINYL TRIFLATES [J].
ARCADI, A ;
CACCHI, S ;
CARNICELLI, V ;
MARINELLI, F .
TETRAHEDRON, 1994, 50 (02) :437-452
[3]  
ARCADI A, 1992, TETRAHEDRON LETT, V33, P3915
[4]   Palladium-catalyzed reaction of o-ethynylphenols, o-((trimethylsilyl)ethynyl)phenyl acetates, and o-alkynylphenols with unsaturated triflates or halides: A route to 2-substituted-, 2,3-disubstituted-, and 2-substituted-3-acylbenzo[b]furans [J].
Arcadi, A ;
Cacchi, S ;
DelRosario, M ;
Fabrizi, G ;
Marinelli, F .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (26) :9280-9288
[5]   Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted α,β-unsaturated sulfoxide [J].
Chen, Z ;
Mocharla, VP ;
Farmer, JM ;
Pettit, GR ;
Hamel, E ;
Pinney, KG .
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (25) :8811-8815
[6]   A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents [J].
Flynn, BL ;
Verdier-Pinard, P ;
Hamel, E .
ORGANIC LETTERS, 2001, 3 (05) :651-654
[7]  
FLYNN BL, IN PRESS BIOORG MED
[8]   Synthesis and pharmacological activity of diarylindole derivatives.: Cytotoxic agents based on combretastatins [J].
Medarde, M ;
Ramos, AC ;
Caballero, E ;
de Clairac, RPL ;
López, JL ;
Grávalos, DG ;
Feliciano, AS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (16) :2303-2308
[9]  
PINNEY GR, 1998, Patent No. 9839323
[10]   A new anti-tubulin agent containing the benzo[b]thiophene ring system [J].
Pinney, KG ;
Bounds, AD ;
Dingeman, KM ;
Mocharla, VP ;
Pettit, GR ;
Bai, R ;
Hamel, E .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (08) :1081-1086