Internal resin capture - A self purification method for the synthesis of C-terminally modified peptides

被引：21

作者：

Davies, M ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 15期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

combinatorial; peptides; solid-phase; linkers;

D O I：

10.1016/S0040-4020(99)00146-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4733 / 4746

页数：14

共 40 条

[1]

ALBERI S, 1988, AM J HUM BIOL, V10, P98

[2]

ALBERICIO F, 1987, INT J PEPT PROT RES, V30, P206

[3]

Allen MJ, 1997, BRIT J PHARMACOL, V120, pP339

[4]

ANTONIOU M, 1994, INT J PEPT PROT RES, V43, P344

[5] MILD PROCEDURE FOR SOLID-PHASE PEPTIDE-SYNTHESIS - USE OF "FLUORENYLMETHOXYCARBONYLAMINO-ACIDS [J].

ATHERTON, E ;

FOX, H ;

HARKISS, D ;

LOGAN, CJ ;

SHEPPARD, RC ;

WILLIAMS, BJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (13) :537-539

[6] PEPTIDE-SYNTHESIS .2. PROCEDURES FOR SOLID-PHASE SYNTHESIS USING N-ALPHA-FLUORENYLMETHOXYCARBONYLAMINO-ACIDS ON POLYAMIDE SUPPORTS - SYNTHESIS OF SUBSTANCE-P AND OF ACYL CARRIER PROTEIN 65-74 DECAPEPTIDE [J].

ATHERTON, E ;

LOGAN, CJ ;

SHEPPARD, RC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (02) :538-546

[7] SOLID-PHASE SYNTHESIS OF PEPTIDE PARA-NITROANILIDES [J].

BURDICK, DJ ;

STRUBLE, ME ;

BURNIER, JP .

TETRAHEDRON LETTERS, 1993, 34 (16) :2589-2592

[8] FUNGAL LIPOPEPTIDE MATING PHEROMONES - A MODEL SYSTEM FOR THE STUDY OF PROTEIN PRENYLATION [J].

CALDWELL, GA ;

NAIDER, F ;

BECKER, JM .

MICROBIOLOGICAL REVIEWS, 1995, 59 (03) :406-422

[9] SENSITIVE SUBSTRATES FOR HUMAN-LEUKOCYTE AND PORCINE PANCREATIC ELASTASE - STUDY OF THE MERITS OF VARIOUS CHROMOPHORIC AND FLUOROGENIC LEAVING GROUPS IN ASSAYS FOR SERINE PROTEASES [J].

CASTILLO, MJ ;

NAKAJIMA, K ;

ZIMMERMAN, M ;

POWERS, JC .

ANALYTICAL BIOCHEMISTRY, 1979, 99 (01) :53-64

[10] C-terminally modified peptides and peptide libraries - Another end to peptide synthesis [J].

Davies, M ;

Bradley, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1997, 36 (10) :1097-1099

← 1 2 3 4 →