Aryl sulfones:: a new class of γ-secretase inhibitors

被引：97

作者：

Teall, M

Oakley, P

Harrison, T

Shaw, D

Kay, E

Elliott, J

Gerhard, U

Castro, JL

Shearman, M

Ball, RG

Tsou, NN

机构：

[1] Neurosci Res Ctr, Merck Sharp & Dohme Res Labs, Dept Med Chem, Harlow CM20 2QR, Essex, England

[2] Neurosci Res Ctr, Merck Sharp & Dohme Res Labs, Dept Mol & Cellular Neurosci, Harlow CM20 2QR, Essex, England

[3] Merck & Co Inc, Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2004.12.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2685 / 2688

页数：4

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