New mutation in ParE in a pneumococcal in vitro mutant resistant to fluoroquinolones

被引：18

作者：

Janoir, C

Varon, E

Kitzis, MD

Gutmann, L

机构：

[1] Univ Paris 06, LRMA, F-75270 Paris 06, France

[2] Hop St Joseph, Serv Bacteriol, F-75674 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 03期

关键词：

D O I：

10.1128/AAC.45.3.952-955.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For an in vitro mutant of Streptococcus pneumoniae selected on moxifloxacin four- to eightfold-increased MICs of new fluoroquinolones, only a twofold-increased MIC of ciprofloxacin, and a twofold-decreased MIC of novobiocin were observed. This phenotype was conferred by two mutations: Ser81Phe in GyrA and a novel undescribed His103Tyr mutation in ParE, outside the quinolone resistance-determining region, in the putative ATP-binding site of topoisomerase IV.

引用

页码：952 / 955

页数：4

共 31 条

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