Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

被引:76
作者
Sanchez, P [1 ]
Clement, V [1 ]
Altaba, ARI [1 ]
机构
[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
关键词
D O I
10.1158/0008-5472.CAN-05-0439
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.
引用
收藏
页码:2990 / 2992
页数:3
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