Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

被引：76

作者：

Sanchez, P ^{[1
]}

Clement, V ^{[1
]}

Altaba, ARI ^{[1
]}

机构：

[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

来源：

CANCER RESEARCH | 2005年 / 65卷 / 08期

关键词：

D O I：

10.1158/0008-5472.CAN-05-0439

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

引用

页码：2990 / 2992

页数：3