Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease

被引：64

作者：

Debeljuh, Natalie ^{[1
]}

Barrow, Colin J. ^{[1
]}

Henderson, Luke ^{[2
]}

Byrne, Nolene ^{[1
]}

机构：

[1] Deakin Univ, Inst Technol Res & Innovat, Geelong, Vic 3217, Australia

[2] Deakin Univ, Sch Life & Environm Sci, Geelong, Vic 3217, Australia

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 22期

关键词：

BETA; STABILIZATION; DENATURATION; PROTEINS; UREA;

D O I：

10.1039/c1cc10377f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.

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收藏

页码：6371 / 6373

页数：3

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