A new class of Rh(III) catalyst containing an aminoalcohol tethered to a tetramethylcyclopentadienyl hydrogenation group for asymmetric transfer of ketones

被引：22

作者：

Cross, DJ

Houson, I

Kawamoto, AM

Wills, M ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Avecia Huddersfield Works, Huddersfield HD2 1FF, W Yorkshire, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2003.11.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The synthesis and application to asymmetric reduction of acetophenone, of a novel class of Rh(III) catalyst containing a tether between the cyclopentadienyl group and a homochiral aminoalcohol, is described. The complex is a highly active catalyst for asymmetric ketone reduction, however it appears to be unstable to the extended reaction conditions. The well-defined stereochemical structure of the catalyst offers potential for significant improvement and 'fine tuning' towards specific substrates. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：843 / 846

页数：4

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