Development of reaction using imines as a radical acceptor and its stereocontrol

This review summarizes the recent progress in the field of radical reaction of imine derivatives, and focuses on the new carbon-carbon bond constructing-methods especially based on intermolecular carbon radical addition to imine derivatives. Among the wide range of radical accepters containing a carbon-nitrogen double bond, it was revealed that the oxime ethers were excellent radical accepters, and a lot of studies have been explored by using oxime ethers. Reactivity of imine derivatives and possible reaction pathways have also been presented. The reaction was extended to one-pot and/or multi-component reactions. Moreover, a high degree of stereocontrol in reaction of acyclic and cyclic imine derivatives was achieved by using triethylborane and diethylzinc.