Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

被引：96

作者：

Smith, Catherine J. ^{[1
]}

Smith, Christopher D. ^{[1
]}

Nikbin, Nikzad ^{[1
]}

Ley, Steven V. ^{[1
]}

Baxendale, Ian R. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 06期

基金：

英国工程与自然科学研究理事会; 美国安德鲁·梅隆基金会;

关键词：

POLYMER-SUPPORTED REAGENTS; FUNCTIONALIZED POLYMERS; MACROPOROUS POLYMER; POROUS MATERIALS; PHASE CHEMISTRY; SCAVENGERS; EFFICIENT; REACTOR; CATALYSTS; MICROREACTORS;

D O I：

10.1039/c0ob00813c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new tools was demonstrated by their application to a flow Staudinger aza-Wittig reaction sequence. Finally, a multistep aza-Wittig, reduction and purification flow process was designed, allowing access to amine products in an automated fashion.

引用

页码：1927 / 1937

页数：11

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