Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A

被引：91

作者：

Zhou, Rong ^{[1
]}

Bai, Yinyang ^{[1
]}

Yang, Rong ^{[1
]}

Zhu, Ying ^{[1
]}

Chi, Xia ^{[2
]}

Li, Lin ^{[1
]}

Chen, Lei ^{[1
]}

Sokabe, Masahiro ^{[3
]}

Chen, Ling ^{[1
,3
]}

机构：

[1] Nanjing Med Univ, Dept Physiol, Lab Reprod Med, 140 Hanzhong Rd, Nanjing 210029, Peoples R China

[2] Nanjing Med Univ, Dept Pediat, Nanjing 210029, Peoples R China

[3] Nagoya Univ, Grad Sch Med, Dept Physiol, Nagoya, Aichi 4668550, Japan

来源：

NEUROPHARMACOLOGY | 2011年 / 60卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Bisphenol-A; Attention-deficit; Hyper-locomotion; GABA(A) receptor (GABA(A)R); Dopamine D1 receptor (DRD1); Long-term potentiation (LTP); LONG-TERM POTENTIATION; NEONATAL EXPOSURE; NONSELECTIVE ATTENTION; ENDOCRINE DISRUPTORS; RECEPTOR; NEURONS; MODULATION; STRESS; NUCLEUS; GABA;

D O I：

10.1016/j.neuropharm.2011.01.031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

If the pregnant and lactating female rats are exposed to environmental levels of bisphenol-A (SPA), their male offspring will display hyperactivity and attention-deficit. In patients with attention-deficit/hyperactivity disorder (ADHD), the size of the amygdala is reported to be reduced. This study examined functional alterations in the basolateral amygdala (BLA) of the postnatal 28-day-old male offspring exposed perinatally to BPA (BPA-rats). We specifically focused on the synaptic properties of GABAergic/dopaminergic systems in the BLA. A single electrical stimulation of the capsule fibers evoked multispike responses with an enhanced primary population spikes (1st-PS) in the BPA-rats. A single train of high-frequency stimulation of the fibers induced NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in BPA-rats, but not in control rats. Also, paired-pulse inhibition (PPI, GABA-dependent) in control rats was reversed to paired-pulse facilitation (PPF) in BPA-rats. Perfusion of slices obtained from BPA-rats with the GABA(A) receptor (GABA(A)R) agonist muscimol blocked the multispike responses and LTP, and recovered PPI. By contrast, the dopamine D1 receptor antagonist SCH23390 abolished LTP and attenuated the increased amplitude of 1st-PS in BPA-rats. Conversely, blockade of GABAAR by bicuculline could produce the multispike responses and PPF in BLA in control rats. Furthermore, in BLA the infusion of SCH23390, muscimol or the NMDAR blocker MK801 ameliorated the hyperactivity and improved the deficits in attention. These findings suggest that the perinatal exposure to BPA causes GABAergic disinhibition and dopaminergic enhancement, leading to an abnormal cortical-BLA synaptic transmission and plasticity, which may be responsible for the hyperactivity and attention-deficit in BPA-rats. This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：789 / 798

页数：10

共 64 条

[1]

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