Solid-phase synthesis of N-acyl-N′-carbamoylguanidines

被引：27

作者：

Lin, PS ^{[1
]}

Ganesan, A ^{[1
]}

机构：

[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期

关键词：

combinatorial chemistry; solid-phase synthesis; thioformamidines; guanidines;

D O I：

10.1016/S0040-4039(98)02174-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amino acids immobilized on polystyrene-Wang or Rink amide resin were reacted with p-nitrophenyl chloroformate to give an activated urethane that was displaced by S-methylisothiourea. Following N-acylation with an acid chloride, the thiomethyl group was displaced by primary or secondary amines with the aid of mercury (II) chloride to yield the unsymmetrically substituted title compounds after resin cleavage. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9789 / 9792

页数：4

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