The preparation of 1,2,4-triazines from α,β-diketo-ester equivalents and their application in pyridine synthesis

被引：38

作者：

Altuna-Urquijo, M

Stanforth, SP ^{[1
]}

Tarbit, B

机构：

[1] Northumbria Univ, Sch Appl Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[2] Seal Sands Chem Ltd, Middlesbrough TS2 1UB, Cleveland, England

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 36期

基金：

英国工程与自然科学研究理事会;

关键词：

1.2,4-triazines; alpha; beta-diketo-esters; aza Diels-Alder reaction;

D O I：

10.1016/j.tetlet.2005.06.163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alpha-Chloro-alpha-acetoxy-beta-keto-esters were prepared from beta-keto-esters in good overall yields. These compounds reacted as alpha,beta-diketo-ester equivalents with amidrazones yielding triazines, generally in good yields, or with an amidrazone and 2,5-norbornadiene in a one-pot aza Diels-Alder reaction to give the corresponding pyridines. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6111 / 6113

页数：3

共 28 条

[1] One-pot synthesis of pyridines or pyrimidines by tandem oxidation-heteroannulation of propargylic alcohols [J].