Risk factors for hypertension in obese women. The role of weight cycling

被引:34
作者
Guagnano, MT
Ballone, E
Pace-Palitti, V
Vecchia, RD
D'Orazio, N
Manigrasso, MR
Merlitti, D
Sensi, S
机构
[1] Univ G dAnnunzio, Dipartimento Med Interna & Sci Invecchiamento, Policlin Colle Ara, Med Clin, I-66100 Chieti, Italy
[2] Univ G dAnnunzio, Lab Biostat, Chieti, Italy
关键词
blood pressure; obesity; weight cycling;
D O I
10.1038/sj.ejcn.1600963
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To study significant factors associated with the risk of hypertension among obese women, with and without a history of weight cycling (WC). Design: Case-control study. Setting: Obesity Clinic of Chieti University, Italy. Subjects: a group of 258 obese women aged 25-64 y (103 cases with hypertension and 155 controls) were recruited. All obese subjects had the same clinical characteristics, were without a family history for hypertension, were nan-smokers, had normal lipidemic profiles and normal glucose tolerance, were not taking any medication and were otherwise healthy. Intervention: In the weight cycling women, the history of WC was established on the basis of at least five weight losses in the previous 5 y due to dieting, with a weight loss of at least 4.5 kg per cycle. A logistic regression model adjusted for confounding variables such as waist-to-hip ratio (WHR) and weight cycling history parameters was used and the odds ratio (OR) with 95% confidence intervals was calculated. Results: The risk of hypertension increases in subjects with larger WHR (OR 7.8; 95% CI 3.4-17.9) and with a positive history for WC (OR 4.1; 95% CI 2.4-6.9). Further, in obese patients with WC, the weight cycling index and the sum of the weight regained are also important risk factors for hypertension. Conclusions: These findings could support the hypothesis that it is the combined exposure of central-type obesity and WC that strongly raises the risk of hypertension. Sponsorship: This work has been financially supported by a grant of Ministero dell'Universita e della Ricerca Scientifica e Tecnologica.
引用
收藏
页码:356 / 360
页数:5
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