Cyclic heptapeptides from the Jamaican sponge Stylissa caribica

被引：58

作者：

Mohammed, Rabab

Peng, Jiangnan

Kelly, Michelle

Hamann, Mark. T. ^{[1
]}

机构：

[1] Univ Mississippi, Dept Pharmacognosy Pharmacol Chem & Biochem, University, MS 38677 USA

[2] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Natl Inst Water & Atmospher Res Ltd, Auckland, New Zealand

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 12期

关键词：

D O I：

10.1021/np060006n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cyclic heptapeptides, stylisin 1( 1) and stylisin 2 ( 2), were isolated and characterized from the Jamaican sponge Stylissa caribica, in addition to the cyclic heptapeptide phakellistatin 13 ( 3) and the known bromopyrrole alkaloids sceptrin (4), stevensine (5), and oroidin (6). The new structures were assigned on the basis of 1D and 2D NMR spectroscopic data, as well as chemical methods for the elucidation of the absolute configuration of amino acids. The peptides and alkaloids have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and antiinflammatory activities.

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页码：1739 / 1744

页数：6

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