Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13

被引：52

作者：

Li, WL

Yi, YH

Wu, HM

Xu, QZ

Tang, HF

Zhou, DZ

Lin, HW

Wang, ZH

机构：

[1] Second Mil Med Univ, Res Ctr Marine Drugs, Sch Pharm, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 01期

关键词：

D O I：

10.1021/np020223y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cyclic heptapeptide phakellistatin 13 (1) had been isolated from the sponge Phakellia fusca Thiele, collected at Yongxing Island of China. Its structure was elucidated as cyclo-(Pro(1)-Trp-Leu-Thr-Pro(2)-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR (600 MHz) analysis. The compound was significantly cytotoxic against the human hepatoma BEL-7404 cell line with an ED50 < 10(-2) mug/mL.

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页码：146 / 148

页数：3

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