When cells get stressed: an integrative view of cellular senescence

被引:316
作者
Ben-Porath, I [1 ]
Weinberg, RA [1 ]
机构
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
关键词
D O I
10.1172/JCI200420663
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cells entering a state of senescence undergo a permanent cell cycle arrest, accompanied by a set of functional and morphological changes. Senescence of cells occurs following an extended period of proliferation in culture or in response to various physiologic stresses, yet little is known about the role this phenomenon plays in vivo. The study of senescence has focused largely on its hypothesized role as a barrier to extended cell division, governed by a division-counting mechanism in the form of telomere length. Here, we discuss the biological functions of cellular senescence and suggest that it should be viewed in terms of its role as a general cellular stress response program, rather than strictly as a barrier to unlimited cycles of cell growth and division. We also discuss the relative roles played by telomere shortening and telomere uncapping in the induction of senescence.
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收藏
页码:8 / 13
页数:6
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