Inhibition of experimental autoimmune neuritis by the immunomodulator linomide

被引:11
作者
Karpati, T [1 ]
Karussis, D [1 ]
Abramsky, O [1 ]
Mizrahi-Koll, R [1 ]
Arbell, I [1 ]
Ovadia, H [1 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Univ Hosp, Dept Neurol, Sch Med, IL-91120 Jerusalem, Israel
关键词
experimental autoimmune neuritis; linomide; LS-2616; peripheral nervous system; sciatic nerve; P2 synthetic peptide; apoptosis;
D O I
10.1016/S0165-2478(98)00070-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Experimental autoimmune neuritis (EAN) is an animal model that shares clinical, pathological and electrophysiological features with the human disease Guillain-Barre syndrome. The synthetic immunomodulatory substance linomide has been successfully used to prevent the development of several experimental autoimmune models in laboratory animals and has been proved to be beneficial in modulating the course of multiple sclerosis in humans. In the present study we demonstrate that oral administration of linomide prevents the development of clinical and histopathological signs of EAN in Lewis rats, inoculated with the P2 (60-70) synthetic peptide. The immunomodulatory effect of linomide on this experimental model of disease was associated with marked apoptosis of lymphocytes in thymus and spleen early after starting the treatment. Furthermore, a downregulation of the endothelial expression of the adhesion molecules ICAM-1 at the target site and LFA-1 on lymphocytes could also contribute to the absence of inflammatory cells in the neuraxis. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:141 / 145
页数:5
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