Bile salts: Natural detergents for the prevention of sexually transmitted diseases

被引:42
作者
Herold, BC
Kirkpatrick, R
Marcellino, D
Travelstead, A
Pilipenko, V
Krasa, H
Bremer, J
Dong, LJ
Cooper, MD
机构
[1] CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA
[2] So Illinois Univ, Sch Med, Dept Med Microbiol & Immunol, Springfield, IL 62901 USA
[3] Rush Med Coll, Dept Microbiol, Chicago, IL 60612 USA
[4] Rush Med Coll, Dept Obstet & Gynecol, Chicago, IL 60612 USA
关键词
D O I
10.1128/AAC.43.4.745
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens have not been reported. To further explore the potential role of bile salts in preventing sexually transmitted diseases, we examined the in vitro activities and cytotoxicities of select bile salts against Chlamydia trachomatis, herpes simplex virus (types 1 and 2), Neisseria gonorrhoeae, and human immunodeficiency virus in comparison to those of nonoxynol-9 and benzalkonium chloride using both primary cells and cell lines derived from the human female genital tract, We found that taurolithocholic acid 3-sulfate and a combination of glycocholic acid and taurolithocholic acid 3-sulfate showed excellent activity against all of the pathogens assayed. Moreover, taurolithocholic acid 3-sulfate alone or in combination was less cytotoxic than nonoxynol-9 and benzalkonium chloride. Thus, taurolithocholic acid 3-sulfate alone or in combination warrants further evaluation as a candidate topical microbicidal agent.
引用
收藏
页码:745 / 751
页数:7
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