Biodegradable miniplates (LactoSorb):: Long-term results in infant minipigs and clinical results

被引:54
作者
Wiltfang, J
Merten, HA
Schultze-Mosgau, S
Schrell, U
Wénzel, D
Kessler, P
机构
[1] Univ Erlangen Nurnberg, Klin & Poliklin Mund Kiefer Gesichtschirurg, Dept Oral & Craniomaxillofacial Surg, Erlangen, Germany
[2] Univ Erlangen Nurnberg, Dept Neurosurg, Erlangen, Germany
[3] Univ Gottingen, Dept Oral & Craniomaxillofacial Surg, D-3400 Gottingen, Germany
[4] Univ Erlangen Nurnberg, Dept Neuropediatry, Erlangen, Germany
关键词
biodegradable miniplates; PIT effect; minipigs;
D O I
10.1097/00001665-200011030-00006
中图分类号
R61 [外科手术学];
学科分类号
摘要
Metallic plates are known for their passive intraosseous transmission in the growing skull. To avoid plate removal, resorbable material with strength comparable to that of metallic plates and predictable resorption would be desirable. This should be accomplished without causing inflammatory complications and foreign body reactions often seen with highly crystalline poly-L-lactic acid or pure polyglycolic acid implants. In an animal experiment in four young Gottingen minipigs, the resorbable poly-L-lactic acid/polyglycolic acid copolymer LactoSorb was tested previously. In addition to testing the mechanical properties, the process of degradation and sub- versus epi- or supraperiosteal application of the miniplate device LactoSorb was evaluated using a frontal cranioosteoplasty model. Furthermore, LactoSorb was used in 10 patients with craniosynostosis or craniofacial trauma. During degradation, the absorbable poly-L-lactic acid/polyglycolic acid miniplates acted like metal plates because they also displayed passive intraosseous transmission in the growing animal model. Degradation took 12 to 18 months and was not delayed by bony incorporation. Their mechanical properties proved to be sufficient in craniofacial surgery. Epiperiosteal plating prolonged the passive intraosseous transmission effect during the first 3 months after surgery. There were no major inflammatory reactions seen in the experimental and/or in the clinical study.
引用
收藏
页码:239 / 243
页数:5
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