共 71 条
An asymmetric conjugate addition reaction of lithium organocopper reagent controlled by a chiral amidophosphine
被引:32
作者:
Kanai, M
Nakagawa, Y
Tomioka, K
[1
]
机构:
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源:
基金:
日本科学技术振兴机构;
日本学术振兴会;
关键词:
asymmetric reactions;
copper and compounds;
lithium and compounds;
D O I:
10.1016/S0040-4020(99)00094-0
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Examination of the behaviors of the chiral amidophosphines 1-14 in the asymmetric conjugate addition reaction of lithium organocopper with chalcone and cycloalkenone revealed that the reaction efficiency is governed by many factors including copper salt, solvent, molecular ratio of copper and organolithium, and the structure of the substrate. The reaction with cycloalkenone gave the adduct in up to 94% ee under the stoichiometric conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:3831 / 3842
页数:12
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